jan 1, 1952 - Medical publication by Mognes Schou on lithium in medicine got the international recognition

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The breakthrough in lithium treatment for mania and the prophylaxis of manic-depressive illness began in 1952, when Erik Strömgren, head of the Aarhus University psychiatric clinic in Risskov, Denmark—who had read the Cade article—suggested to a staff psychiatrist at the hospital, Mogens Schou, that he might undertake a randomly controlled trial of lithium in mania. Random controls were just being introduced in psychiatric drug trials in those years. Schou randomized the mania patients with a flip of a coin to lithium or placebo, and in 1954 he published the results in a British journal. Schou concluded, “The lithium therapy appears to offer a useful alternative [to electroconvulsive therapy (ECT)] since many patients can be kept in a normal state by administration of a maintenance dose” (19).

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