aug 8, 1665 - The Great Plague forces the closure of the University of Cambridge, where Isaac Newton is a student. Newton retires to his home in Lincolnshire for safety and stays there for two years. During this time alone, Newton will make groundbreaking discoveries in mathematics, calculus, mechanics and optics, and lay the foundations for his books Philosophiæ Naturalis Principia Mathematica and Optiks
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aug 8, 1665
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~ 361 years ago