Plague of Justinian (jan 1, 540 – jan 1, 654)

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The Plague of Justinian (541–542) was a pandemic that afflicted the Eastern Roman (Byzantine) Empire, especially its capital Constantinople, the Sassanid Empire, and port cities around the entire Mediterranean Sea. One of the deadliest plagues in history, this devastating pandemic resulted in the deaths of an estimated 25 million (at the time of the initial outbreak that was at least 13% of the world's population) to 50 million people in two centuries of recurrence.

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