Antonine Plague, Roman Empire, 5–10 million dead (jan 1, 165 – jan 1, 180)
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"The Antonine Plague of 165 to 180 AD, also known as the Plague of Galen, was an ancient pandemic brought to the Roman Empire by troops who were returning from campaigns in the Near East. Scholars have suspected it to have been either smallpox or measles." -Wikipedia
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