Periods
Task1.1-Characterize the cellular dynamic interactions between human tumor cells and zebrafish innate immune cells (6m)Task1.2Sample of an long eventTask1.2- Determine the cellular players that govern tumour rejection vs engraftment. (6m)Task2.1-Identify possible human molecules that mediate engratment vs rejection 6mTask1.3- Identify the human and zebrafish molecules that control tumour clonal dynamics and their interplay with the zebrafish microenvironment. (6m)Task1.4-Test the previously selected candidate genes (1,5Y)Task1.5- Study the behavior of zPDX of advanced colorectal cancer patients with synchronous vs metachronous metastasesTask3.1-Screen FDA approved small molecules library for tumour rejectionTask3.2-Screen best hits in pre-clinical mouse tumour modelsTask4.1- Screen for the regressors and progressor´s molecular signatures in patients subjected to immunotherapyTask4.2- Test if zPDX engraftment can be a surrogate for immunogenicity ie help select patients for immunotherapy.
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