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9 Jan 2018
9 Jan 2018
Blaser learned about the Campylobacter species (C.fetus & C.jejuni) through his patient
New relative of Campylobacter (Helicobacter pylori) was discovered
Blaser met Dr. Barry Marshall and talked about H.pylori
Dr. Marshall and Robin Warren won Nobel Price for showing that eradicating H.pylori with antibiotics cure ulcers
Blaser moved to NYU and set up a laboratory to study H.pylori
Blaser was sick, infected with Salmonella paratyphi from a trip to Bangladesh and India. Cure with an antibiotic, co-trimoxazole
Anne Miller suffered a miscarriage and had childbirth fever (puerperal sepsis). Cured with penicillin (one of the first patient)
Louis Pasteur demonstrated meat decay and disease was caused by multiplication of microbes/germs.
Alexander Fleming found Staph was killed off by a common bread mold Penicillium in a petri dish. He grew more and called it penicillin
Howard Florey and Ernst Chain led an Oxford team to develop ways to mass produce penicillin in Illinois.
Streptomycin was developed from soil bacteria to fend off M.tuberculosis
Health-care providers prescribed 258 million course of antibiotics to people in the U.S.
Scientist analyzing 30 thousand year old bacteria from Yukon permafrost found that the bacteria are resistant to antibiotics
Pharmaceutical manufacturers discovered animals fed antibiotics gain more weight quickly than those fed on drug-free diet
70-80% of all antibiotics sold in U.S. are used to fatten up cattle
Consumer Union tested and found 13 of 14 Staphylococcus samples from pork are resistant to at least 1 drug
Study conducted in cities of Michigan and Ohio found antibiotic-resistant bacteria in all water source
2 new drugs, thalidomide and diethylstilbestrol, use to treat common problem in pregnancy
Dragutin Schwarz recognized that the stomach must contain acid for an ulcer to occur.
Dr. Robin Warren noticed that there'e bacteria inside the stomach. This bacteria can cause signs of inflammation called gastritis.
Warren and Marshall isolate and cultured the bacteria, called Campylobacter pylori.
Marshall experimented with himself by swallowing a culture of H.pylori. He showed that H.pylori cause gastritis
Blaser and Guillermo Perez-Perez developed the 1st blood test to accurately identify carries of H.pylori based on their antibodies.
Blaser and Perez-Perez created a library of H.pylori genes within E.coli cells (mass produce them). They found CagA (cytotoxin-associated gene).
They collaborated with Dr. Abraham Nomura to study the relationship between H.pylori and risks for stomach cancer. They found H.pylori increase the risk of stomach cancer.
Blaser and his team, along with John Atherton, try to find a relation between H.pylori and acid reflux/heartburn (GERD).
Dr. Joan Reibman work with Blaser to find relationship between asthma and H.pylori. They found that people with H. pylori were less likely to have asthma than people without H.pylori
Blaser's team and Dr. Yu Chen reproduce Blaser's findings with another population using NHANES III data. Their results remain the same.
Blaser and Alberatine Beard research and find the connection between height and H.pylori
Blaser and his team, along with Ilseung Cho and Laurie Cox, set up experiments to find the relationship between the usage of antibiotics and obesity/fat gaining
Blaser and Jessica Dunne talked about trying to find a relation between H.pylori and celiac disease.
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