Events
1942: nitrogen mustard first used [3]1968: SCLC divided into limited disease (LD) and extensive disease (ED) stages [3]1969: Cyclophosphamide single-agent chemotherapy shown to be effective [3]1969: Medical Research Council: superior survival benefit with primary radical radiation therapy compared to surgery [3]March 2019: Atezolizumab approved as first line treatment for ES-SCLC by FDAPeriods
1959-1962 Recognition of small cell lung cancer (SCLC) as a separate category from other lung cancers [3]1970s: Combination therapy shows dramatic responses. Fraction of patients experienced very long-term disease-free survival [3]1980s: Combination cisplatin/etoposide with chemotherapy becomes treatment of choice [3]1990s: Chemotherapy used for relapsed disease [4]2000s: Development and study of new therapeutic targets for SCLC with mixed results [3]
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