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PD-1 first discovered PD-1 deficiency implicated in immunity PD-L1 blockade shows preclinical efficacy in myeloma Discovery of PD-L1 and PD-L2 PD-1 blockade shows preclinical efficacy in melanoma Phase I trial begins for nivolumab BMS acquires Medarex for $2.4B FDA approves two anti-PD-1 antibodies for melanoma

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