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Giotto completes his work on the Scrovegni Chapel in Padua.
Dante writes his poem the Divine Comedy
Petrarch is named the poet laureate of Rome.
Brunelleschi designs the dome for the Florence Cathedral.
Medici family becomes the head of the city-state of Florence.
Johannes Gutenberg invents the printing press.
The Ottoman Empire captures the city of Constantinople, signaling an end to the Byzantine Empire.
Lorenzo de Medici becomes head of the city-state of Florence. He is one of the great patrons of the arts
Henry VII becomes king of England beginning the reign of the House of Tudor.
Boticelli completes the painting The Birth of Venus.
Christopher Columbus discovers the Americas.
Leonardo da Vinci paints the Last Supper.
Vasco da Gama arrives in India after sailing around the southern tip of Africa from Portugal.
Michelangelo begins his work on the sculpture David.
Leonardo da Vinci paints the Mona Lisa.
Michelangelo begins his painting on the ceiling of the Sistine Chapel.
Henry VIII becomes king of England.
Raphael paints his masterpiece The School of Athens.
Sir Thomas More publishes his work Utopia on political philosophy.
Martin Luther posts his 95 theses on the door of the Church of Wittenberg. This signals the start of the Reformation.
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