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Johannes Gutenberg invents the printing pressExplorer Christopher Columbus sets out from Spain and discovers the New WorldVasco de Gama arrives in India after sailing around the souther tip of Africa from PortugalLeonardo da Vinci paints the Mona LisaHenry VII becomes king of England beginning the reign of the House of TudorErasmus writes Praise of FollySir Thomas More publishes UtopiaMartin Luther posts his 95 ThesesFerdinand Magellan begins his circumnavigation of the worldCharles V (Holy Roman Empire) sacks RomeHenry VIII separates the Church of England from the Catholic ChurchElizabeth I becomes Queen of EnglandFall of Constantinople to the TurksSpain expells Jews and MuslimsCalvin publishes his Institutes of the Christian ReligionCopernicus publishes De Revolutionibus Orbium CoelestiumBeginning of the Council of TrentMichelangelo completes painting ceiling of Sistine ChapelMachiavelli writes The PrinceHernán Cortés begins conquest of AztecsCharles V condemns Luther at Diet of Worms
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