12 окт 1767 г. - At the Foundling Hospital in London, Dr. William Watson becomes the first physician to conduct a controlled clinical trial, selecting 32 boys and girls of similar age who have not yet had smallpox

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He divides them into three groups in order to test treatments before inoculation for smallpox, with one group receiving a mixture of mercury and jalap, another senna glycoside, and the third getting no pre-treatment at all.

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