1 янв 1974 г. - Mefloquine utilized for Malaria Treatment

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The development of mefloquine was a collaborative achievement of the U.S. Army Medical Research and Development Command, the World Health Organization (WHO/TDR), and Hoffman-La Roche, Inc. After World War II, about 120 compounds were produced at the Walter Reed Army Institute of Research (WRAIR) in an attempt to find replacements for quinine. Preclinical trials coincided with the appearance of chloroquine-resistant falciparum malaria in areas of American military concern in Southeast Asia, and South America. Ultimately, WRAIR developed WR142490 (mefloquine), a 4-quinoline methanol. Mefloquine's efficacy in preventing falciparum malaria when taken regularly was first reported in 1974 (Rieckmann et al., 1974). Soon after, it also was shown to be a successful treatment agent (Trenholme et al., 1975). Clinical evidence of parasites resistant to mefloquine began to appear in Asia around the time of the drug's general availability in 1985 (Hoffman et al., 1985).
(Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance., n.d.)

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