1 янв 541 г. - Bubonic - Plague of Justinian

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Genetic studies of modern and ancient Yersinia pestis DNA suggest that the origin of the Justinian plague was in Central Asia. The most basal or root level existing strains of the Yersinia pestis as a whole species are found in Qinghai, China.

pandemic that afflicted the Byzantine (Eastern Roman) Empire and especially its capital, Constantinople, as well as the Sasanian Empire and port cities around the entire Mediterranean Sea

Deaths of an estimated 25–50 million people during two centuries of recurrence, a death toll equivalent to 13–26% of the world's population at the time of the first outbreak.

https://en.wikipedia.org/wiki/Plague_of_Justinian

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