23 сент 2017 г. - First time a base editor is used to edit DNA of embryos Location: Sun Yat-Sen University, China Method: Base editor Journal: Protein & Cell Type of embryo: Disease treated: beta thalassemia Results: Efficiency was 7-25.9%. Most of the edited embryos were mosaics, with percentage of repaired cells being 20-75%. No off-target effects were found, but only the “top 10 potential off-target sites” were analysed, so there could have been unintended edits in the unexamined parts of the genome.
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