30
/it/
AIzaSyAYiBZKx7MnpbEhh9jyipgxe19OcubqV5w
April 1, 2024
Public Timelines
FAQ
Menu
Public Timelines
FAQ
Public Timelines
FAQ
For education
For educational institutions
For teachers
For students
Open cabinet
For educational institutions
For teachers
For students
Open cabinet
Creare
Close
Create a timeline
Public timelines
Library
FAQ
Scaricare
Export
Creare una copia
Premium
Integrare nel sito Web
DNA Timeline
è stato aggiornato 14 dic 2018
2
0
440
Share
Autori
Created by
Devanshi Bhavsar
List of Edits
Attachments
Comments
Isaiah L-Blanchard
Great work
3 mag 2023
Reply
Eventi
Friedrich Miescher (1869) -identified "nuclein" (today's DNA) in the nuclei of white blood cells of humans -this credit tends to wrongly be given to Watson and Crick
Oswald Avery, Colin MacLeod, Maclyn McCarty (1941) -identified that DNA is the transforming principle by building on Griffith's mouse experiment -injected purified versions of DNA and protein into mice -DNA killed the mice, protein did not
James Watson & Francis Crick (1953) -developed the double helix model of DNA based on data gathered by Rosalind Franklin and Maurice Wilkins -an accurate representation of DNA in modern times
Rosalind Franklin & Maurice Wilkins (1952) -investigated the structure of DNA using X-Ray diffraction techniques -photo 51 is a famous x-ray crystallography image demonstrating a helical structure to DNA -helped Watson and Crick construct an accurate DNA model
Gregor Mendel (1866) -discovered the basic principles of genetics with his pea plant experiments -used the terms dominant and recessive to explain his experimental results -called his findings as "invisible" traits (called genes today)
Frederick Griffith (1928) -came up with the "Transforming Principle" that can change phenotype by his experiment with mice -the heat-killed virulent bacteria was able to transmit the virus into the nonvirulent bacteria
Erwin Chargaff (1950) Summarized major findings into... Chargaff's Rules: -adenine pairs with thymine -guanine pairs with cytosine -bases form weak hydrogen bonds
Alfred Hershey & Martha Chase (1952) -conclusively confirmed that DNA is the transforming factor -"Blender Experiment" -Protein(S) radioactively labeled--ends up outside in the liquid -DNA radioactively labeled--ends up inside the pellet
Phoebus Levene (1909) -discovered the basic components of nucleic acids -figured how the components fit together, including the nucleotides
Linus Pauling (1952) -came up with the triple-stranded DNA model(wrong) -induced Watson and Crick to come up with the correct model
Thomas Hunt Morgan (1908) -discovered that chromosomes are related to phenotype and also that genes are on chromosomes, by his work with fruit flies -the male fruit flies with white eyes had a specific X chromosome
William Astbury (1943) -developed X-Ray diffraction patterns -had developed an image similar to Rosalind Franklin's photo 51 before she did
Werner Arber (1962) -came up with the concept of restriction and modification enzymes, produced by bacteria, being able to defend against invading viruses -based on experiments done with lambda phages
Paul Berg (1972) -created the first recombinant DNA molecule -new discoveries in biochemistry helped with this discovery -individual genes could now be isolated and inserted into a cell
Fred Sanger (1977) -developed rapid sequencing procedure for DNA (Sanger Method) -used to determine order of bases in DNA strand
Kary Mullis (1983) -developed PCR (Polymerase Chain Reaction)--an easier method of obtaining a specific sequence of DNA -used to identify causative agents to infections -also used to screen patients for genetic diseases
Francis Collins (1989) -found the cystic fibrosis gene -used "positional cloning" -allows the ability to identify a disease gene without knowing about the functional abnormality
[CRISPR] Cas9 and PAM discovered (May 2005) -discovery made by Alexander Bolotin while studying the bacteria Streptococcus thermophilus -(Cas9-protospacer adjacent motif) a novel cas gene that encodes for a large protein predicted to have nuclease activity -(PAM) a sequence required for target recognition
Celera Organization and US Department of Energy (1990) -created the Human Genome Project to try to sequence the entire human genome -an international effort that lasted into 2003
Marshall Nirenberg & H. Gobind Khorana (1968-year of Nobel Prize) -Nirenberg discovered the first triplet/codon -codon: a sequence of three bases that codes for one of 20 amino acids -used test tube techniques for experiments -Khorana demonstrated the role of nucleotides in protein synthesis -both cracked the genetic code
George Garnow (1954) -proposed that the genetic code was determined by triplets of nucleotides -basic contribution to the modern genetic theory
Periodi
History of DNA Timeline
About & Feedback
Accordo
Privatezza
Biblioteca
2024
©
Time.Graphics
Support 24/7
Cabinet
Get premium
Donate
The service accepts bank transfer (ACH, Wire) or cards (Visa, MasterCard, etc). Processed by Stripe.
Secured with SSL
Excellent (Trustpilot Reviews)
Based on 115+ reviews
Write your own review on
Trustpilot.com
Comments