1 dic 78 anni - Characteristic Signs of Malaria Infection

Descrizione:

"Characteristic signs of malaria infection are fever and flu-like symptoms, including headaches and muscle or joint pain. These usually begin after an incubation period of 10 to 14 days after the infective bite, during which the malaria parasite first inhabits the liver and then quietly multiplies in the blood. Classically, the fever is intermittent, recurring every few days, corresponding to the erythrocytic cycle. Each time the infected cells burst, liberating new merozoites, toxic metabolites and malarial antigens are also released. The body's immune system responds with a fever. In P. falciparum infections, fevers would occur on days 1, 3 and 5, whereas in P. malariae, fevers would occur on days 1, 4 and 7, and so forth. It is important, however, to remember two points. First, malarial fevers, especially in P. falciparum infections, do not always show cyclic temperature changes. Second, P. falciparum malaria can kill within 48 hours of the first signs, so it is essential that medical help is sought if one develops such symptoms after a visit to a region where malaria is a problem." (When Was Malaria First Discovered and by Whom? How Is the Disease Transmitted? What Are Its Effects?, 2000)

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