23 sett 2017 anni - First time a base editor is used to edit DNA of embryos Location: Sun Yat-Sen University, China Method: Base editor Journal: Protein & Cell Type of embryo: Disease treated: beta thalassemia Results: Efficiency was 7-25.9%. Most of the edited embryos were mosaics, with percentage of repaired cells being 20-75%. No off-target effects were found, but only the “top 10 potential off-target sites” were analysed, so there could have been unintended edits in the unexamined parts of the genome.
Aggiunto al nastro di tempo:
Data:
23 sett 2017 anni
Adesso
~ 8 years ago