1 gen 1968 anni - 1968 Hipótesis "ARN primero"

Descrizione:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331698/

The general idea that, in the development of life on the Earth, evolution based on RNA replication preceded the appearance of protein synthesis was first proposed over 40 yr ago (Woese 1967; Crick 1968; Orgel 1968). It was suggested that catalysts made entirely of RNA are likely to have been important at this early stage in the evolution of life, but the possibility that RNA catalysts might still be present in contemporary organisms was overlooked. The unanticipated discovery of ribozymes (Kruger et al. 1982; Guerrier-Takada et al. 1983) initiated extensive discussion of the role of RNA in the origins of life (Sharp 1985; Pace and Marsh 1985; Lewin 1986) and led to the coining of the phrase “the RNA World” (Gilbert 1986).