The fifth vial was poured out on the ‘seat of the beast,’ as the office of the Papacy lost their power in 1798 AD.
Shortly after the French Revolution, the Papal States were invaded by French forces, and they removed Pope Pius VI, who died in exile in Valence (France) in 1799.
Their 1,260-year reign was ended by the hand of Elohim, but they repented not.
They blasphemed Elohim because of the pains and sores of losing their authority.