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AIzaSyAYiBZKx7MnpbEhh9jyipgxe19OcubqV5w
April 1, 2024
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Atualizado 1 meses atrás
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1763 John Hunter (1728–1793) "The famous Scotsborn anatomist and surgeon, discovered remodelling, the process by which new bone is laid down in the body and the old bone is destroyed or resorbed."
1790 Sir Astley Cooper (1768–1841) "Surgeon and anatomist, recognised that the age-related decline in bone density increased the risk of fracture."
1830 Jean Lobstein (1777–1835) "French pathologist [...] credited with developing the term ‘osteoporosis’ or porous bone in the 1830s to describe holes in bones which he found were larger in some patients than others."
1934 Preston Kyes (1875–1949) and Potter "estrogen levels [...] affect bone density"
1936 Fuller Albright (1900–1969) "[noted] a deficiency of osteoblasts in the affected bone. [...] Discovered that frail bones were more common in postmenopausal women, particularly those who underwent an early menopause. [...] He developed the first effective treatment for osteoporosis by prescribing estrogen"
1955 Alexander Cooke (1899–1999) "Defined osteoporosis as a disease of inadequate bone formation from lack of ‘matrix’. He noted the lack of osteoblasts to replace osteoclastic erosions"
1960s Herbert Andre Fleisch (1933–2007) Discovery of biphosphonates
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