29
/pt/
pt
AIzaSyAYiBZKx7MnpbEhh9jyipgxe19OcubqV5w
April 1, 2024
Criar
Public Timelines
Biblioteca
FAQ
For education
Cabinet
For educational institutions
For teachers
For students/pupils
Baixar
Export
Criar uma cópia
Incorporar ao site
Visualizações 181
0
0
SCLC treatment evolution
Criada
Halocy
⟶ Atualizado 4 mar 2020 ⟶
List of edits
Comentários
Eventos
1942: nitrogen mustard first used [3]
1968: SCLC divided into limited disease (LD) and extensive disease (ED) stages [3]
1969: Cyclophosphamide single-agent chemotherapy shown to be effective [3]
1969: Medical Research Council: superior survival benefit with primary radical radiation therapy compared to surgery [3]
March 2019: Atezolizumab approved as first line treatment for ES-SCLC by FDA
Períodos
1959-1962 Recognition of small cell lung cancer (SCLC) as a separate category from other lung cancers [3]
1970s: Combination therapy shows dramatic responses. Fraction of patients experienced very long-term disease-free survival [3]
1980s: Combination cisplatin/etoposide with chemotherapy becomes treatment of choice [3]
1990s: Chemotherapy used for relapsed disease [4]
2000s: Development and study of new therapeutic targets for SCLC with mixed results [3]