1 ago 2020 ano - > BEST 3 (13,222 participants) Primary objectives: diagnosis rate per 1000 person-years Results: 1. Cytosponge + endoscopy diagnosed 140/6434 BE cases while endoscopy alone diagnosed 13/6388 BE cases. The rate ratio adjusted for cluster randomisation is 10.6. 2. 221/1654 participants tested positive for TFF3 after Cytosponge test, they underwent endoscopy. 131/221 of them were diagnosed with BE or cancer. Conclusion: Cytosponge detect 10x BE cases than the usual GP route

Descrição:

Study Design: multi-centre, pragmatic, randomized controlled trial in 109 socio demographically diverse general practice clinics in England. Randomisation at GP level and at participant level.
Participants: 13,222 participants
Methods: Patient receive either endoscopy + standard care or Cytosponge-TFF3 procedure + endoscopy + standard care
Data collection time: March 20, 2017 to March 21, 2019.
Limitations:
1. Around 10% participants had a low-confidence result even after a repeat test.
2. There are slightly more women than men who underwent Cytosponge-TFF3 test, this is not representative of true men to women ratio for this cancer.
3. Quality of endoscopies varies across 24 hospitals
Funding: Cancer Research UK, National Institute for Health Research, the UK National Health Service, Medtronic, and the Medical Research Council.

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