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A BRIEF HISTORY OF TCAs!
This timeline outlines a brief history of tricyclic anti-depressants that rapidly developed due the "explosive birth" of psychopharmacology.
5 months ago
Synthesis of Cholorpromazine by Rhône-Poulenc's chief chemist, Paul Charpentier from antihistamines initially developed by Rhône-Poulenc in the 1940s. Cholorpromazine - marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Anti-histamines - allergy relief drug used to trea hay-fever (e.g. nasal congestion, sneezing, hives, caused by pollen, dust mites or animal allergy).
Psychiatric effects of Cholorpromazine first noticed in Paris, 1952.
Cholorpromazine was the first widely used psychiatric drug, by 1955 it was generating significant revenue as a anti-psychotic. Chemists decided to explore the derivatives of cholorpromazine.
Imipramine, usually sold under the brand name Tofranil was the first tricyclic anti-depressant used to treat depression.
Tricyclic Anti-depresants were developed amid the "explosive birth" of psychopharmacology. Psychopharmacology - the scientific study of the effects drugs have on mood, sensation, t hinking, and behavior.
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