may 6, 1527 - Charles V of the Holy Roman Empire Sacks Rome
At the Battle of Pavia in 1525, Francis I of France had been defeated and captured by Charles V of the Holy Roman Empire, causing diplomatic alliances to shuffle including Pope Clement VII shifting from Charles to the side of the Spanish and Francis. Charles needed to pay his near mutinous soldiers, so in retaliation, he allowed his German and Spanish troops to sack Rome and capture Clement. With Rome destroyed, its art treasures stolen, and its population decimated, the event marked the end of the High Renaissance in Rome.
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