dec 28, 2004 - Cannabis and KYNA
Description:
Exogenous cannabinoids such as cannabidiol or Δ9-tetrahydrocannabinol are known to stimulate IDO enzyme activity in dependence of cannabinoid receptor activation [120]. This stimulation, together with the pharmacological inhibition of the kynurenine 3-monooxygenase (KMO) enzyme [123] may enhance endogenous KYNA levels indirectly, through the kynurenine pathway, which will result in an enhanced reduction in NMDA receptor activity via the antagonizing effect of KYNA.
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